第一作者：Zejun Sun

通讯作者：Hong-bin Sun, Qionglin Liang

合写作者：Guo, Liutao

发表刊物：Biosensors and Bioelectronics

卷号：211

影响因子：10.7

DOI码：10.1016/j.bios.2022.114367

所属单位：Department of Chemistry, Northeastern University

教研室：物理化学

刊物所在地：Netherlands

摘要：Neurotransmitter dopamine (DA) has been implicated in a variety of physiological and pathological processes, realizing its low detection limit and high sensitivity analysis is of great significance for early disease diagnosis. Herein, we propose a simple pyrolysis approach for dispersing Fe-sites onto the N-doped graphene support (denoted as Fe/N-GR) to construct an electrochemical biosensor for DA detection. The fully exposed Fe-sites guaranteed the well-defined active center for electrochemical oxidation of DA. The Fe/N-GR electrochemical biosensor achieves an ultra-low detection limit for DA of 27 pM with a linear range of 50 pM-15 nM. Specifically, the Fe/N-GR electrochemical biosensor exhibits favorable sensitivity and enzyme-level molecular identification ability in the selective detection of DA versus other typical redox-active interferents. What’s more, the detection of dopamine in real human serum samples verifies the applicability of the developed sensor. Our results demonstrate a promising means of using fully exposed metal-site subnanometric catalysts for electrochemical sensing applications.

关键字：Dopamine,Fully expose Fe-Sites,Oligo-layer graphene,Electrochemical biosensor,Subnanometric catalysts

论文编号：WOS:000806387700005

学科门类：理学

一级学科：化学

页面范围：114367

ISSN号：0956-5663

是否译文：否