第一作者：Dong Li, Lei Liu

通讯作者：Hong-bin Sun, Gang Zhang

合写作者：Yu Tian, Yongjian Ai, Zhike Tang

发表刊物：Tetrahedron

期号：27-28

卷号：73

影响因子：1.8

DOI码：10.1016/j.tet.2017.05.065

所属单位：Department of Chemistry, Northeastern University

教研室：物理化学

刊物所在地：ENGLAND

摘要：The N-unsubstituted 4-aryl-1H-1,2,3-triazoles were synthesized via the acetic acid promoted cycloaddition between P-nitrostyrenes with sodium azide under transition-metal-free conditions in a continuous flow microreactor. The continuous-flow microreactor provided a safe environment for the dangerous reagents NaN3 and nitroalkene, and offered such a rapid procedure that the triazoles were formed in less than 4 min. In addition, the excess sodium azide was quenched by the by-product HNO2 in the presence of acetic acid. The scale-up experiment proved again that the yield did not drop in the flow reaction. Moreover, the synthesis of N-unsubstituted 1,2,3-triazole was also explored via a one pot reaction with aldehyde, nitromethane and sodium azide, and this reaction was monitored with an "in-tube retention time gradient" (IT-RIG) technology, which may be a novel application of the continuous-flow microreactor. (C) 2017 Elsevier Ltd. All rights reserved.

关键字：Continuous flow microreactor；1,2,3-Triazole；Nitroalkene；Acid promote；In-tube retention time gradient

论文编号：WOS:000403998200020

学科门类：理学

一级学科：化学

页面范围：3959-3965

ISSN号：0040-4020

是否译文：否