教育经历

1999 – 2004     Lanzhou Medical College, Department of Preventive Medicine, School of Public Health

                         M.D. – Medicine

2004 – 2007     Fourth Military Medical University, Department of Cell Biology, School of Basic Medical Sciences

                        M.S. – Cell Biology

2007 – 2010     Fourth Military Medical University, Department of Cell Biology, School of Basic Medical Sciences

                        Ph.D. – Cell Biology

博士后及访学经历

2010.10 – 2012.09     Department of Medicine, Northwestern University Feinberg School of Medicine

 Postdoctoral Fellow

2017.12 – 2019.01     Breast Caner Center, Baylor College of Medicine. Exchange Vistor

工作经历

2013 –                     Associate professor

      Northeastern University College of Life and Health Sciences

研究方向

Cancer biology;

Neurodegenerative diseases;

Alternative pre-mRNA splicing.

科研项目

ACTIVE

National Natural Sciences Foundation of China 81971015           01/01/2020 – 12/31/2023

the Fundamental Research Funds for Central Public Welfare Research Institutes of China N2120003     01/01/2021 – 12/31/2022

Special Projects of the Central Government in Guidance of Local Science and Technology Development 2022JH6/100100025 01/01/2022 – 12/31/2022

COMPLETED

The Fundamental Research Funds for Central Public Welfare Research Institutes of China N141008001/7          01/01/2015 –12/31/2017                        

National Natural Sciences Foundation of China 31301108                             01/01/2014 – 12/31/2016

National Undergraduate Innovative Test Program 151167                                                                                    03/01/2015 – 05/31/2016

the Fundamental Research Funds for Central Public Welfare Research Institutes of China N130520002              01/01/2014 – 12/31/2015

发表论文（^#共同第一作者，*通讯作者）

[1] Li, D.D., Zhang, Y.H., Zhang, W.*, Zhao, P. *, Meta-Analysis of Randomized Controlled Trials on the Efficacy and Safety of Donepezil, Galantamine, Rivastigmine, and Memantine for the Treatment of Alzheimer's Disease, Frontiers in neuroscience, 13 (2019) 472.

[2] Zhang, H., Brown, R.L., Wei, Y., Zhao, P., Liu, S., Liu, X., Deng, Y., Hu, X., Zhang, J., Gao, X.D., Kang, Y., Mercurio, A.M., Goel, H.L., Cheng, C.*, CD44 splice isoform switching determines breast cancer stem cell state, Genes & development, 33 (2019) 166-179.

[3] Wang, Z., Zhang, Y.H., Zhang, W., Gao, H.L., Zhong, M.L., Huang, T.T., Guo, R.F., Liu, N.N., Li, D.D., Li, Y., Wang, Z.Y.* and Zhao, P.* Copper chelators promote nonamyloidogenic processing of AbetaPP via MT1/2 /CREB-dependent signaling pathways in AbetaPP/PS1 transgenic mice. Journal of pineal research, 65 (2018) e12502.

[4] Wang, Z., Zhang, Y.H., Guo, C., Gao, H.L., Zhong, M.L., Huang, T.T., Liu, N.N., Guo, R.F., Lan, T., Zhang, W., Wang, Z.Y.* and Zhao, P.* Tetrathiomolybdate Treatment Leads to the Suppression of Inflammatory Responses through the TRAF6/NFkappaB Pathway in LPS-Stimulated BV-2 Microglia. Frontiers in aging neuroscience, 10 (2018) 9.

[5] Li, Y., Li, Z.X., Jin, T., Wang, Z.Y.* and Zhao, P.* Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases. Journal of Alzheimer's disease : JAD, 57 (2017) 395-409.

[6] Li, D.D., Zhang, W., Wang, Z.Y.* and Zhao, P.* Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer's Disease: A Meta-Analysis of Case-Control Studies. Frontiers in aging neuroscience, 9 (2017) 300.

[7] Zhao, P., Xu, Y., Wei, Y., Qiu, Q., Chew, T.L., Kang, Y.and Cheng, C. The CD44s splice isoform is a central mediator for invadopodia activity. Journal of cell science, 129 (2016) 1355-1365.

[8] Wang, S.J., Cui, H.Y., Liu, Y.M., Zhao, P., Zhang, Y., Fu, Z.G., Chen, Z.N.andJiang, J.L. CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells. Oncotarget, 6 (2015) 243-257.

[9] Hu, Y., Bi, X., Zhao, P., Zheng, H.andHuang, X. Cytotoxic Activities, SAR and Anti-Invasion Effects of Butylphthalide Derivatives on Human Hepatocellular Carcinoma SMMC7721 Cells. Molecules, 20 (2015) 20312-20319.

[10] Zhao, P., Damerow, M.S., Stern, P., Liu, A.H., Sweet-Cordero, A., Siziopikou, K., Neilson, J.R., Sharp, P.A.andCheng, C. CD44 promotes Kras-dependent lung adenocarcinoma. Oncogene, 32 (2013) 5186-5190.

[11] Zhang, W. #, Zhao, P. #, Xu, X.L., Cai, L., Song, Z.S., Cao, D.Y., Tao, K.S., Zhou, W.P., Chen, Z.N.and Dou, K.F. Annexin A2 promotes the migration and invasion of human hepatocellular carcinoma cells in vitro by regulating the shedding of CD147-harboring microvesicles from tumor cells. PLoS One, 8 (2013) e67268.

[12] Cui, H.Y., Guo, T., Wang, S.J., Zhao, P., Dong, Z.S., Zhang, Y., Jiang, J.L., Chen, Z.N.andYu, X.L. Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway. Biochemical and biophysical research communications, 419 (2012) 517-522.

[13] Zhao, P.#, Zhang, W. #, Wang, S.J #., Yu, X.L., Tang, J., Huang, W., Li, Y., Cui, H.Y., Guo, Y.S., Tavernier, J., Zhang, S.H., Jiang, J.L.andChen, Z.N. HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells. Hepatology, 54 (2011) 2012-2024.

[14] Zhao, P. #, Zhang, W. #, Tang, J., Ma, X.K., Dai, J.Y., Li, Y., Jiang, J.L., Zhang, S.H.andChen, Z.N. Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147. Cancer science, 101 (2010) 387-395.

[15] Ma, X.K., Wang, L., Li, Y., Yang, X.M., Zhao, P., Tang, H., Zhu, P., Li, L.andChen, Z.N. HAb18G/CD147 cell-cell contacts confer resistance of a HEK293 subpopulation to anoikis in an E-cadherin-dependent manner. BMC cell biology, 11 (2010) 27.

[16] Wu, Y.M., Tang, J., Zhao, P., Chen, Z.N. and Jiang, J.L. Enhanced expression of Hab18g/CD147 and activation of integrin pathway in HCC cells under 3-D co-culture conditions. Cell biology international, 33 (2009) 199-206.

[17] Wu, Y.M., Tang, J., Zhao, P., Chen, Z.N. and Jiang, J.L. Morphological changes and molecular expressions of hepatocellular carcinoma cells in three-dimensional culture model. Experimental and molecular pathology, 87 (2009) 133-140.

[18] Tang, J., Wu, Y.M., Zhao, P., Jiang, J.L. and Chen, Z.N. Betaig-h3 interacts with alpha3beta1 integrin to promote adhesion and migration of human hepatoma cells. Experimental biology and medicine, 234 (2009) 35-39.

[19] Dai, J.Y., Dou, K.F., Wang, C.H., Zhao, P., Lau, W.B., Tao, L., Wu, Y.M., Tang, J., Jiang, J.L.andChen, Z.N. The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells. BMC cancer, 9 (2009) 337.

[20] Tang, J., Wu, Y.M., Zhao, P., Yang, X.M., Jiang, J.L.andChen, Z.N. Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways. Cellular and molecular life sciences: CMLS, 65 (2008) 2933-2942.

[21] Ku, X.M., Liao, C.G., Li, Y., Yang, X.M., Yang, B., Yao, X.Y., Wang, L., Kong, L.M., Zhao, P. and Chen, Z.N. Epitope mapping of series of monoclonal antibodies against the hepatocellular carcinoma-associated antigen HAb18G/CD147. Scandinavian journal of immunology, 65 (2007) 435-443.